Penza: Humboldt State’s defense shows signs of improvement against Azusa Pacific

first_imgARCATA >> Simply based on what was right in front of us entering the 2016 season, the Humboldt State defense was going to be a work in progress.That’s just the reality you find yourself in when you lose 10 starters from a unit that was the best in the Great Northwest Athletic Conference a season ago. And that’s what prompted HSU head coach Rob Smith to say that as the defense tries to find its rhythm with so many new pieces, his Jacks will have to rely on the offense to carry the way. Through …last_img read more

Epigenetics Rising in Consciousness of Geneticists, Embryologists

first_imgThe old story of genetics was that all the information is in genes, and when sperm and egg unite, it’s only the combination of genes from parents that affect the offspring.  That view has been under challenge for years now as geneticists and embryologists find more and more evidence for additional heritable factors that affect development of the embryo and the life of the offspring.    It should have been obvious that more than genes unite at conception.  Both egg and sperm are much more than sets of naked genes.  Nature reported that human sperm contains protein factors that guide and direct the embryo.1  Researchers primarily at Howard Hughes Medical Institute found that distinctive chromatin packages genes for embryo development.  Prior to this, they said, “the epigenetic contributions of sperm chromatin to embryo development have been considered highly limited.”  They found numerous heritable factors:Here we show that the retained nucleosomes are significantly enriched at loci of developmental importance, including imprinted gene clusters, microRNA clusters, HOX gene clusters, and the promoters of stand-alone developmental transcription and signalling factors.  Notably, histone modifications localize to particular developmental loci.  Dimethylated lysine 4 on histone H3 (H3K4me2) is enriched at certain developmental promoters, whereas large blocks of H3K4me3 localize to a subset of developmental promoters, regions in HOX clusters, certain noncoding RNAs, and generally to paternally expressed imprinted loci, but not paternally repressed loci.  Notably, trimethylated H3K27 (H3K27me3) is significantly enriched at developmental promoters that are repressed in early embryos, including many bivalent (H3K4me3/H3K27me3) promoters in embryonic stem cells.  Furthermore, developmental promoters are generally DNA hypomethylated in sperm, but acquire methylation during differentiation.  Taken together, epigenetic marking in sperm is extensive, and correlated with developmental regulators.So it’s not just the gift of DNA; it’s the packaging.  “We provide several lines of evidence that the parental genome is packaged and covalently modified in a manner consistent with influencing embryo development.”  The factors in both egg and sperm affect “developmental decisions and imprinting patterns.”    In a related topic, Science Daily said that the rise in awareness of epigenetics among researchers is blurring the line in the old nature-nurture debate.  For instance, doctors used to think that having a certain mutation guaranteed a patient will have a genetic disease.  Other factors, though, such as a mother’s diet, can affect the outcome: “epigenetic factors play a surprisingly large role in the disease risk that gets passed down through the generations,” the article said.  While permanent genetic mutations are the largest factor, “what is not often explained is that less permanent changes to our DNA also significantly influence our risk for disease,” said Mark Johnston, editor of Genetics.  “We tend to view disease risk as a tug of war between nature and nurture, but this study shows that nature and nurture are more closely related than we had imagined.”1.  Hammoud et al, “Distinctive chromatin in human sperm packages genes for embryo development,” Nature 460, 473-478 (23 July 2009) | doi:10.1038/nature08162.It should be noted that nature vs nurture is an example of the either-or fallacy.  Some evolutionary psychologists agree (see PhysOrg): they called for “tossing out the nature-nurture debate, which they say has prevailed for centuries in part out of convenience and intellectual laziness.”  Can you think of other factors that should be added to the equation?  How about intelligence and choice?  Without those, it renders human beings as mere determined products of physical and environmental factors.  Your genetics and environment are not forcing you to read these words right now.  Think about that.  There – you made another choice.    Epigenetics is poised to mount another major assault on evolutionary theory.  One of the points made in the upcoming film Darwin’s Dilemma* is that epigenetic factors pile difficulty upon difficulty for Darwin, because evolutionary theory needs to account not only for genetic information in DNA, but the epigenetic information that controls development.  There are many factors beyond the gene library that determine a body plan.  What orchestrates and choreographs the orderly localization of cell types in a developing embryo?  What manages their differentiation?  What commits them to the roles they will play?  We are only beginning to understand these higher-order programs.  If neo-Darwinists were hard-pressed to explain the genetic code by the accumulation of mutations filtered by natural selection, wait till they have to account for the epigenetic code.*Scheduled for release in mid-September: see Illustra Media.(Visited 17 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more

Jeff Horn lets Manny Pacquiao know he’s ready for a May 2019 bout

first_imgPrivate companies step in to help SEA Games hosting Grace Poe files bill to protect govt teachers from malicious accusations PH underwater hockey team aims to make waves in SEA Games PLAY LIST 02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games02:11Trump awards medals to Jon Voight, Alison Krauss Oil plant explodes in Pampanga town Don’t miss out on the latest news and information. The problem, however, is that the other welterweight World champions have scheduled fights in March and April.Shawn Porter, a former sparring partner of Pacquiao’s, will defend the WBC title on March 9 while Errol Spence will stake the IBF championship on March 16.Terrence Crawford, who is with Top Rank, will go up against Amir Khan for the defense of the WBO belt.Keith Thurman, the owner of the WBA Super World welterweight belt, was just coming off a majority decision win over Josesito Lopez on January 26.This leaves Horn, who owns two regional titles from WBA and WBO, as a viable opponent for Pacquiao but the Filipino shrugged off his former foe’s wishes.“I was willing to do a rematch with them but they didn’t want to. And now that I am back on top and they are coming off a loss, they are asking for a rematch. No way,” said Pacquiao in the Manila Bulletin report.Sports Related Videospowered by AdSparcRead Next “That’s a coincidence because May suits me perfectly also,” said Horn (19-1-1) in his Instagram account. MOST READ Horn does have the upper hand against Pacquiao (61-7-2) albeit through a controversial unanimous decision win to take the WBO World welterweight title back in July of 2017.Pacquiao has since bounced back from that shock loss with back-to-back wins, the first of which to take the WBA 147-lb title from Lucas Matthysse via knockout in July 2018 and the last one a unanimous decision victory over Adrien Broner in January 2019 to retain the strap.As per Manila Bulletin, Pacquiao told Premier Boxing Champions—the company that handles the best welterweights—that a May fight suits him since this is the time the Philippine Senate goes into recess to accommodate the 2019 midterm elections.ADVERTISEMENT ‘We are too hospitable,’ says Sotto amid SEA Games woescenter_img PDEA chief backs Robredo in revealing ‘discoveries’ on drug war US judge bars Trump’s health insurance rule for immigrants Jeff Horn of Australia, left, and Manny Pacquiao of the Philippines, right, lands a left to during their WBO World Welterweight title fight in Brisbane, Australia, Sunday, July 2, 2017. APMANILA, Philippines—Jeff Horn is ready to step up and face Manny Pacquiao for a potential rematch, if it what he teases comes to fruition.The Australian teacher-turned-prize fighter expressed through Instagram his willingness to fight the legendary Filipino with Pacquiao eyeing another match potentially in May.ADVERTISEMENT LATEST STORIES View comments Ex-NBA exec joins ONE Championship as new VP International SEA Games hosting troubles anger Duterte ‘We are too hospitable,’ says Sotto amid SEA Games woeslast_img read more

ExKnick Charles Oakley Heading to Trial In August Over

Former New York Knicks player Charles Oakley  (AP Photo/Richard Drew, File)NEW YORK (AP) — Former New York Knicks great Charles Oakley has chosen to go to trial in August on charges he struck a security guard at Madison Square Garden.Oakley appeared briefly before a Manhattan judge on Friday. He rejected a conditional dismissal that would have left him with a clean record after six months of good behavior.Oakley became a fan favorite when he played for the Knicks from 1988 to 1998. But he’s had a falling out with the organization in recent years.On Feb. 8, he sat a few rows from Knicks owner James Dolan at a game against the Los Angeles Clippers. Security approached Oakley early in the game and a fracas ensued. Oakley was removed from the building and handcuffed.Oakley says he didn’t do anything wrong. read more

US broadcaster loses Myanmar outlet over Rohingya name

first_imgLogo of Radio Free Asia. Photo: CollectedA US government-affiliated broadcaster that provides news to countries in Asia where freedom of information is restricted is losing its partner in Myanmar after refusing to stop using the word “Rohingya” to describe an oppressed Muslim minority.Monday was the last day DVB Media Group’s network would carry Radio Free Asia’s television broadcasts, RFA spokesman Rohit Mahajan said. He said RFA told Myanmar authorities that it was unwilling to bow to their pressure to use a term other than Rohingya.About 700,000 Rohingya have fled to neighbouring Bangladesh since Myanmar’s government launched a violent counterinsurgency campaign last August in western Myanmar, where most Rohingya lived. Many people in Myanmar call the Rohingya “Bengali” to reflect the contention that they are illegal migrants from Bangladesh rather than natives.The government refuses to recognize the Rohingya as an official ethnic minority and denies most the right to citizenship and its privileges.Myanmar is the second Southeast Asian nation in 10 months where RFA has lost access to local broadcasters. Cambodia last August prohibited local FM stations from carrying RFA programming, one of several actions restricting the media in what was seen as a move to silence critical voices ahead of a general election this July.Mahajan said RFA had been broadcasting on DVB’s channel since early October last year. A 7 May memo about DVB’s case from the government broadcasting agency Myanma Radio and Television to private broadcasters said the direct use of the “controversial word ‘Rohingya'” was a violation of contractual codes to which broadcasters are bound.A statement by RFA president Libby Liu provided Monday to The Associated Press declared that the US broadcaster “will not compromise its code of journalistic ethics, which prohibits the use of slurs against ethnic minority groups. RFA will continue to refer to the Rohingya as the ‘Rohingya’ in our reports. Use of other terms, even those that fall short of being derogatory, would be inaccurate and disingenuous to both our product and our audience.””By forbidding the use of the word ‘Rohingya,’ Myanmar’s government is taking an Orwellian step in seeking to erase the identity of a people whose existence it would like to deny,” she said. “RFA will continue to provide audiences in Myanmar with access to trustworthy, reliable journalism, particularly when reporting on issues that local and state-controlled media ignores and suppresses.”Mahajan said RFA’s programming for Myanmar would remain available on its website, on Facebook and YouTube and on shortwave radio, and its reporters will continue to work in the country.In Cambodia, the cessation of RFA broadcasts on local media last year was followed by the closing under pressure of its office and in November by the arrest of two of its former reporters on espionage charges that are generally considered to be attempts to intimidate.RFA, which is loosely modeled on longtime broadcaster Radio Free Europe, carries broadcasts to China, Cambodia, North Korea, Laos and Vietnam as well as Myanmar. It is funded by the US government but run by an independent board.DVB – the Democratic Voice of Burma – was originally established in 1992 as a shortwave radio station in Norway to beam uncensored news to Myanmar when it was still under military rule. It did not immediately respond to a request for comment on its relationship with RFA.last_img read more

250000 mt paddy to be procured from farmers Minister

first_imgProthom Alo File PhotoFood minister Sadhan Chandra Majumder on Tuesday said the government has planned to procure some 250,000 metric tonnes of paddy directly from farmers so that they can enjoy the benefits of farming.The food minister came up with the disclosure while addressing a press conference at the secretariat, reports UNB.”The government previously decided to procure 1200,000 tonnes of rice and 150,000 tonnes of paddy. But, now it has decided to buy 250,000 tonnes more as farmers are being deprived of the fair price of paddy due to its bountiful production,” he said.With the addition one, he said, the total paddy procurement of the government will now stand at 400,000 mts.”The paddy will be bought at Tk 26 per kg. The government has so far managed to procure 30,000 mts of paddy from farmers. Paddy won’t be bought for the second time from the farmers enlisted by the Agriculture Department,” the minister said.Agriculture minister Abdur Razzaque who was also present at the press conference said, “The government will increase the procurement from 400,000 tonnes to 2/1 tonnes further, if necessary.””The prime minister is very concerned at the low price of paddy. Yesterday, the prime minister said profit has to be ensured for framers within the shortest possible time and for that we’ll buy more paddy from them,” Razzaque said.The ongoing food grain procurement programme which started on 25 April will continue till 31 August.Earlier, farmers at different parts of the country staged protests in different ways demanding fair prices of their produce as they have been counting huge losses.Students of different educational institutions of different parts of the country also had helped farmers harvest their paddy to minimize their losses.Mill owners are reportedly buying maximum rice at lower prices in haor areas.The production cost of per maund of rice, including the labourer cost, is said to be Tk 1,000 while its selling price is only Tk 550 to Tk 750 at the local market.last_img read more